We have been the DXA quality assurance site for many NIH-funded studies, CDC, and many more. Dr. Shepherd holds the patent that Hologic uses to measure body composition. He has also served as a past president of the ISCD and has either chaired or been a participant in all ISCD Position Development Conferences.

We work closely with the manufacturers and maintain workstations for Hologic and GE systems with the rights to use that software on scans other than those at our site. Our involvement in DXA quality assurance involves tasks such as,

  • Reviewing and revising DXA image data to ensure consistency by defining the same regions of interest within and among participants so that analyses of demographic differences and longitudinal change are assured that differences are not contaminated by differing definitions of body parts
  • Harmonizing data acquired for a Lunar DXA with data subsequently acquired from a Hologic scanner, so that investigators can examine changes in body composition and bone mineral density from different waves of participants, which may include creating a new master archive storage, cross-calibration equations, longitudinal correction and calibration of DXA data
  • Performing quality control checks on all DXA scans to insure correct participant alignment, appropriate location and accurate positioning of all regions of interest
  • Defining a protocol for ensuring consistency within and among participants’ DXA scan
  • Establishing procedures for continued quality control checks, reanalysis, and data generation for ongoing scans, which may include site manuals, training presentations/materials for site personnel, methods for validating DXA personnel

Below you will find past and current QA studies conducted at SRL, as well as QA-related publications. For inquiries, please contact us for more information.

Current Studies


Dual-energy x-ray absorptiometry (DXA) scan analysis and quality control review for NHANES 2018-2022

National Health and Nutrition Examination Survey (NHANES)

In this study, we are working on NHANES 2018-2022 to review the existing procedures manuals and update as needed by detailing procedures for obtaining the DXA scans for the protocol, perform longitudinal calibrations and cross-calibrations, and provide correction factors, if necessary. Specifically, we will be looking at DXA scans of the hip, spine, VFA spine, and whole body acquired at NHANES mobile examination centers. This data, along with data from similar studies will be used to examine age, sex, and racial/ethnic differences during the life cycle and to explore the relationship between body composition and behavioral factors such as diet and physical activity.

IMPAACT cover photo

IMPAACT 2009: Pharmacokinetics, Feasibility, Acceptability, and Safety of Oral Pre-Exposure Prophylaxis for Primary HIV Prevention during Pregnancy and Breast Feeding in Adolescents and Young Women and their Infants

IMPAACT 2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants

International Maternal Pediatric Adoloscent AIDS Clinical Trials (IMPAACT) Network

Our work with IMPAACT is divided between two studies: IMPAACT 2009 and IMPAACT 2010. IMPAACT 2009 is a study that evaluates daily oral Truvada PrEP in pregnant and lactating women. IMPAACT 2010 is a Phase III study of Virologic Efficacy and safety of Dolutegravir-containing versus Efavirenz-containing Antiretroviral therapy regimens in HIV-1-infected pregnant women and their infants. In both studies, our role is to monitor changes in bone mineral density (BMD), which will include central analysis of spine, femur, and whold body DXA scans. The IMPAACT 2009 study provides an important opportunity to study the effect of PrEP use and lactation on bone mass in young women who are yet to achieve peak bone mass. The IMPAACT 2010 study represents an important opportunity to learn more about the effects of the regimens on maternal and infant bone and renal outcomes.

Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS)

HANDLS

The HANDLS study is a multidisciplinary, community-based, prospective longitudinal epidemiologic study examining the influence of race and socioeconomic status (SES) on the development of age-related health disparities among socioeconomically diverse African Americans and whites in Baltimore. This study investigates whether health disparities develop or persist due to differences in SES, differences in race, or their interaction. Similar to our work with NHANES, we are working on HANDLS to provide DXA analysis and quality control for their body composition and bone mineral density data. We are in the process of establishing procedures manuals and will review/update them as needed by detailing procedures for obtaining the DXA scans for the protocol, perform longitudinal calibrations and cross calibrations, and provide corrections factors, if necessary.

Extended use of NHANES Visceral Adiposity Cancer Risk Factors to GE Systems

The NHANES VAT measures will become the national reference data for VAT upon its release since there isn’t any other representative sample of VAT. However, the NHANES data was acquired on one make of DXA system, Hologic. VAT measures on Hologic DXA systems are substantially different than on GE systems, which complicate the pooling of VAT measures from different systems in multi-center clinical trials and make it difficult to compare VAT measures over time when a patient is scanned on different systems. Furthermore, with GE systems accounting for approximately 50% of the DXA clinical installation base, this means that half of the DXA users won’t be able to access the new NHANES VAT reference data. The objective of this study is to determine the relationship between Hologic and GE Lunar system for VAT measurements in children and adults, repost the NHANES VAT data in GE units, and provide cutoff points relevant for high risk of cancer and metabolic conditions.

Past Studies


Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY)

National Institute of Diabetes and Digestive and Kidney Diseases

The TODAY study was a nationwide research study to compare the efficacy and safety of three interventions to treat adolescents and youth with type 2 diabetes. The primary outcome was time to treatment failure due to loss of glycemic control, defined as hemoglobin A1c >= 8% for 6 months.  Secondary outcomes included measures of beta cell function and insulin resistance, body composition, nutrition, physical activity and aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life, and psychological outcomes.  The influence of individual and family behaviors on treatment response and the relative cost-effectiveness of the three treatment arms were also evaluated. This study has provided information fundamental to improving treatments and outcomes for youth with type 2 diabetes. Learn more.

National Institute of Child Health and Human Development

Bone Mineral Density in Childhood Study

BMDCS

The BMDCS (2001-2011) offered an unprecedented opportunity to identify predictors of the timing and magnitude of peak bone mass, a major determinant of osteoporosis in later adulthood. BMDCS investigators provided reference curves for bone accrual and linear growth velocity that are comparable to the Centers for Disease Control and Prevention linear growth and weight gain curves for children and adolescents. The reference curves generated by this carefully executed study provided the gold standard for normal bone accrual for generations to come. The study’s results enable practitioners to identify the adverse effects that chronic illness has on bone. Additionally, the results have clarified the effects that the timing of pubertal onset have on bone density and linear growth, as well as the need for height adjustment for dual-energy X-ray absorptiometry results in children. Learn more.

BeMyKids Study: Bone Mineral Accretion in Young Children

National Institute of Child Health and Human Development

Led by Dr. Heidi Kalkwarf, the BeMyKids study seeks to understand bone mineral accrual in children 1 to 5 years of age. A glaring deficit is the inability to evaluate bone health of children younger than 5 years due to lack of appropriate bone density reference data. This gap is problematic as there are numerous clinical conditions (e.g., neuromuscular disease, cancer, glucocorticoid treatment, extreme prematurity) that threaten bone health in this young age group. The findings from this study will facilitate medical care of children with chronic medical conditions that threaten bone health, and it will develop and validate novel methods for bone and body composition assessment in this age range. It will also add generalizable knowledge to enhance understanding of the growing skeleton, and its relationship to motor and somatic development. Learn more.

Safety Study of a Tenofovir-containing Drug Regimen for the Prevention of Mother-to-child Transmission of HIV and HBV – Tenofovir in Pregnancy (TiP) Study

TiP Study on the ClinicalTrials.gov site

The Tenofovir in Pregnancy (TiP) study was designed to test the safety of an antiretroviral combination containing TDF in pregnant women co-infected with HIV and HBV and their infants in Guangxi, China. The study’s objectives were to evaluate the renal, liver, and bone mineral density effects of TDF, administered from the second trimester of pregnancy, to women and their infants through a year postnatally. Learn more.

IMPAACT cover photo

IMPAACT P1084s: Maternal and Infant Monitoring for Evidence of Toxicity Related to Tenofovir Exposure: The Bone and Kidney Health Substudy of PROMISE

International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT)

P1084s is a nested, comparative substudy of HIV-1-infected women and their infants randomized in PROMISE (Promoting Maternal and Infant Survival Everywhere) to receive a maternal tenofovir-containing regimen or no maternal tenofovir-containing regimen during pregnancy or breastfeeding for prevention of mother-to-child transmission. The substudy was designed to examine bone, renal and growth outcomes of tenofovir exposure during pregnancy or during breastfeeding in 1077BF and 1077FF. Learn more.

DXA QA/QC Publications

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75 entries « 1 of 3 »

Fu, B C; Hullar, M A J; Randolph, T W; Franke, A A; Monroe, K R; Cheng, I; Wilkens, L R; Shepherd, J A; Madeleine, M M; Marchand, L Le; Lim, U; Lampe, J W

Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study Journal Article

In: Am J Clin Nutr, 111 (6), pp. 1226-1234, 2020, ISSN: 1938-3207 (Electronic) 0002-9165 (Linking).

Links | BibTeX | Tags: Adiposity, Aged, Bacteria, Betaine, Biomarkers, blood, cardiometabolic, Cardiovascular Diseases, Carnitine, Choline, classification, Cohort Studies, Cross-Sectional Studies, ethnology, Female, Gastrointestinal Microbiome, genetics, Humans, immunology, inflammation, isolation & purification, Male, metabolism, Methylamines, microbiology, microbiome, Middle Aged, tmao

Bourgeois, B; Fan, B; Johannsen, N; Gonzalez, M C; Ng, B K; Sommer, M J; Shepherd, J A; Heymsfield, S B

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality Journal Article

In: J Cachexia Sarcopenia Muscle, 10 (1), pp. 84-94, 2019, ISSN: 2190-6009 (Electronic) 2190-5991 (Linking).

Links | BibTeX | Tags: Absorptiometry, Adolescent, Adult, Aged, Arm, Bioimpedance analysis, diagnostic imaging, Echogenicity, Electric Impedance, Female, Hand, Humans, Knee, Leg, Male, Middle Aged, Muscle, Muscle quality, Muscle Strength, Phase angle, Photon, physiology, Sarcopenia, Shape Up, Skeletal, Strength, Young Adult

Brandt, K R; Scott, C G; Miglioretti, D L; Jensen, M R; Mahmoudzadeh, A P; Hruska, C; Ma, L; Wu, F F; Cummings, S R; Norman, A D; Engmann, N J; Shepherd, J A; Winham, S J; Kerlikowske, K; Vachon, C M

Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer Journal Article

In: Breast Cancer Res, 21 (1), pp. 118, 2019, ISSN: 1465-542X (Electronic) 1465-5411 (Linking).

Links | BibTeX | Tags: Aged, Automation, Breast, Breast cancer, Breast Density, Breast Neoplasms, Case-Control Studies, diagnosis, diagnostic imaging, Early Detection of Cancer, Female, Humans, instrumentation, Mammography, methods, Middle Aged, Reproducibility of Results, Risk, Sensitivity and Specificity, Tissue asymmetry, Tumor Burden, Volumetric density

Engmann, N J; Scott, C; Jensen, M R; Winham, S J; Ma, L; Brandt, K R; Mahmoudzadeh, A; Whaley, D H; Hruska, C B; Wu, F F; Norman, A D; Hiatt, R A; Heine, J; Shepherd, J; Pankratz, V S; Miglioretti, D L; Kerlikowske, K; Vachon, C M

Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition Journal Article

In: Cancer Epidemiology, Biomarkers & Prevention, 28 (8), pp. 1324-1330, 2019, ISSN: 1538-7755 (Electronic) 1055-9965 (Linking).

Links | BibTeX | Tags: Body Mass Index, Breast, Breast Density, cytology, Female, Humans, Longitudinal Studies, Mammography, methods, Middle Aged, pathology, physiology, Postmenopause, Premenopause, Risk Factors, Women's Health

Engmann, N J; Scott, C G; Jensen, M R; Winham, S; Miglioretti, D L; Ma, L; Brandt, K; Mahmoudzadeh, A; Whaley, D H; Hruska, C; Wu, F; Norman, A D; Hiatt, R A; Heine, J; Shepherd, J; Pankratz, V S; Vachon, C M; Kerlikowske, K

Combined effect of volumetric breast density and body mass index on breast cancer risk Journal Article

In: Breast Cancer Res Treat, 177 (1), pp. 165-173, 2019, ISSN: 1573-7217 (Electronic) 0167-6806 (Linking).

Links | BibTeX | Tags: 80 and over, Adult, Aged, Body Mass Index, Breast cancer, Breast Density, Breast Neoplasms, Case-Control Studies, Disease Susceptibility, Early Detection of Cancer, epidemiology, etiology, Female, Humans, mammographic density, Mammography, Mass Screening, Menopause, Middle Aged, pathology, Public Health Surveillance, Registries, Risk

Hada, M; Oh, H; Pfeiffer, R M; Falk, R T; Fan, S; Mullooly, M; Pollak, M; Geller, B; Vacek, P M; Weaver, D; Shepherd, J; Wang, J; Fan, B; Mahmoudzadeh, A P; Malkov, S; Herschorn, S; Brinton, L A; Sherman, M E; Gierach, G L

Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy Journal Article

In: Breast Cancer Res, 21 (1), pp. 81, 2019, ISSN: 1465-542X (Electronic) 1465-5411 (Linking).

Links | BibTeX | Tags: Adult, Biomarkers, blood, Breast Density, Breast neoplasm, Breast Neoplasms, Cross-Sectional Studies, diagnosis, Female, Humans, Image-Guided Biopsy, Insulin-like growth factor, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, mammographic density, Mammography, metabolism, Middle Aged, Risk Factors

Maskarinec, G; Hullar, M A J; Monroe, K R; Shepherd, J A; Hunt, J; Randolph, T W; Wilkens, L R; Boushey, C J; Marchand, L Le; Lim, U; Lampe, J W

Fecal Microbial Diversity and Structure Are Associated with Diet Quality in the Multiethnic Cohort Adiposity Phenotype Study Journal Article

In: J Nutr, 149 (9), pp. 1575-1584, 2019, ISSN: 1541-6100 (Electronic) 0022-3166 (Linking).

Links | BibTeX | Tags: Adiposity, Aged, cohort, Cohort Studies, Diet, diet quality, epidemiology, Feces, Female, Gastrointestinal Microbiome, gut microbiome, Humans, Male, microbiology, Middle Aged, multiethnic, Phenotype

Mullooly, M; Puvanesarajah, S; Fan, S; Pfeiffer, R M; Olsson, L T; Hada, M; Kirk, E L; Vacek, P M; Weaver, D L; Shepherd, J; Mahmoudzadeh, A; Wang, J; Malkov, S; Johnson, J M; Hewitt, S M; Herschorn, S D; Sherman, M E; Troester, M A; Gierach, G L

Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy Journal Article

In: Cancer Prev Res (Phila), 12 (12), pp. 861-870, 2019, ISSN: 1940-6215 (Electronic) 1940-6215 (Linking).

Links | BibTeX | Tags: Adult, Age Factors, Aged, Algorithms, Breast, Breast Density, Breast Neoplasms, Computer-Assisted, Cross-Sectional Studies, diagnosis, diagnostic imaging, epidemiology, Epithelium, Female, Fibrocystic Breast Disease, Humans, Image Interpretation, Image-Guided Biopsy, Logistic Models, Mammography, methods, Middle Aged, pathology, Photon, prevention & control, Risk Factors

Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies

Ng, B K; Sommer, M J; Wong, M C; Pagano, I; Nie, Y; Fan, B; Kennedy, S; Bourgeois, B; Kelly, N; Liu, Y E; Hwaung, P; Garber, A K; Chow, D; Vaisse, C; Curless, B; Heymsfield, S B; Shepherd, J A

Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies Journal Article

In: Am J Clin Nutr, 110 (6), pp. 1316-1326, 2019, ISSN: 1938-3207 (Electronic) 0002-9165 (Linking).

Links | BibTeX | Tags: Absorptiometry, Adipose Tissue, Adolescent, Adult, Anthropometry, blood, Body Composition, Cross-Sectional Studies, diabetes, diagnostic imaging, Female, HDL, Humans, Imaging, Insulin, Knee, Lipoproteins, Male, Middle Aged, Obesity, Photon, physiology, Principal Component Analysis, Shape Up, Strength, Three-Dimensional, Triglycerides, Young Adult

Panizza, C E; Lim, U; Yonemori, K M; Cassel, K D; Wilkens, L R; Harvie, M N; Maskarinec, G; Delp, E J; Lampe, J W; Shepherd, J A; Marchand, L Le; Boushey, C J

Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study Journal Article

In: Nutrients, 11 (6), 2019, ISSN: 2072-6643 (Electronic) 2072-6643 (Linking).

Links | BibTeX | Tags: Abdominal, Adiposity, Adult, Aged, Asian Americans, Caloric Restriction, Dash, Diet, diet therapy, East Asian American, Female, Hawaii, Humans, intermittent energy restriction, Intra-Abdominal Fat, Male, Mediterranean, Mediterranean diet, methods, Middle Aged, Obesity, physiopathology, Pilot Projects, randomized trial, Reducing, total adiposity, Treatment Outcome, visceral adipose tissue

Shieh, Y; Scott, C G; Jensen, M R; Norman, A D; Bertrand, K A; Pankratz, V S; Brandt, K R; Visscher, D W; Shepherd, J A; Tamimi, R M; Vachon, C M; Kerlikowske, K

Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype Journal Article

In: Breast Cancer Res, 21 (1), pp. 48, 2019, ISSN: 1465-542X (Electronic) 1465-5411 (Linking).

Links | BibTeX | Tags: Aged, Biomarkers, Body Mass Index, Breast Density, Breast Neoplasms, Case-Control Studies, epidemiology, Estrogen, etiology, Female, genetics, Humans, Mammographic breast density, Middle Aged, Odds Ratio, pathology, Prevalence, Prevention, Receptors, Risk Assessment, Risk Factors, Tumor

Strand, F; Azavedo, E; Hellgren, R; Humphreys, K; Eriksson, M; Shepherd, J; Hall, P; Czene, K

Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study Journal Article

In: Breast Cancer Res, 21 (1), pp. 8, 2019, ISSN: 1465-542X (Electronic) 1465-5411 (Linking).

Links | BibTeX | Tags: Breast, Breast cancer, Breast Density, Breast Neoplasms, Case-Control Studies, Computer-Assisted, Delayed Diagnosis, diagnostic imaging, Early detection, Early Detection of Cancer, False Negative Reactions, Female, Humans, Image Processing, mammographic density, Mammography, Mass Screening, methods, Middle Aged, pathology, prevention & control, Prospective Studies, Retrospective Studies, Screening, Time Factors, Tumor Burden

Alba, D L; Farooq, J A; Lin, M Y C; Schafer, A L; Shepherd, J; Koliwad, S K

Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans Journal Article

In: Journal of Clinical Endocrinology & Metabolism, 103 (9), pp. 3194-3204, 2018, ISSN: 1945-7197 (Electronic) 0021-972X (Linking).

Links | BibTeX | Tags: Abdominal, Adiposity, Adult, Aged, Anthropometry, Asian Americans, blood, Blood Glucose, Body Composition, Body Mass Index, ethnology, European Continental Ancestry Group, Female, Fibrosis, Humans, Hydroxyproline, Insulin Resistance, Male, metabolism, methods, Middle Aged, Obesity, pathology, physiology, physiopathology, statistics & numerical data, Subcutaneous Fat

Hong, J; Hatchell, K E; Bradfield, J P; Bjonnes, A; Chesi, A; Lai, C Q; Langefeld, C D; Lu, L; Lu, Y; Lutsey, P L; Musani, S K; Nalls, M A; Robinson-Cohen, C; Roizen, J D; Saxena, R; Tucker, K L; Ziegler, J T; Arking, D E; Bis, J C; Boerwinkle, E; Bottinger, E P; Bowden, D W; Gilsanz, V; Houston, D K; Kalkwarf, H J; Kelly, A; Lappe, J M; Liu, Y; Michos, E D; Oberfield, S E; Palmer, N D; Rotter, J I; Sapkota, B; Shepherd, J A; Wilson, J G; Basu, S; de Boer, I H; Divers, J; Freedman, B I; Grant, S F A; Hakanarson, H; Harris, T B; Kestenbaum, B R; Kritchevsky, S B; Loos, R J F; Norris, J M; Norwood, A F; Ordovas, J M; Pankow, J S; Psaty, B M; Sanghera, D K; Wagenknecht, L E; Zemel, B S; Meigs, J; Dupuis, J; Florez, J C; Wang, T; Liu, C T; Engelman, C D; Billings, L K

Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations Journal Article

In: Journal of Clinical Endocrinology & Metabolism, 103 (4), pp. 1380-1392, 2018, ISSN: 1945-7197 (Electronic) 0021-972X (Linking).

Links | BibTeX | Tags: Adolescent, Adult, African Americans, Aged, analogs & derivatives, blood, Body Mass Index, Child, epidemiology, ethnology, European Continental Ancestry Group, Female, Gene Frequency, Genetic Loci, genetics, Genome-Wide Association Study, Hispanic Americans, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, United States, Vitamin D, Vitamin D Deficiency, Young Adult

Kerlikowske, K; Scott, C G; Mahmoudzadeh, A P; Ma, L; Winham, S; Jensen, M R; Wu, F F; Malkov, S; Pankratz, V S; Cummings, S R; Shepherd, J A; Brandt, K R; Miglioretti, D L; Vachon, C M

Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers: A Case-Control Study Journal Article

In: Ann Intern Med, 168 (11), pp. 757-765, 2018, ISSN: 1539-3704 (Electronic) 0003-4819 (Linking).

Links | BibTeX | Tags: Aged, Automation, Breast Density, Breast Neoplasms, Case-Control Studies, Computer-Assisted, diagnostic imaging, Early Detection of Cancer, Female, Humans, Mammography, methods, Middle Aged, Radiographic Image Interpretation, Risk Assessment, San Francisco, Sensitivity and Specificity, Time Factors

Rice, M S; Tamimi, R M; Bertrand, K A; Scott, C G; Jensen, M R; Norman, A D; Visscher, D W; Chen, Y Y; Brandt, K R; Couch, F J; Shepherd, J A; Fan, B; Wu, F F; Ma, L; Collins, L C; Cummings, S R; Kerlikowske, K; Vachon, C M

Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics Journal Article

In: Breast Cancer Res Treat, 170 (1), pp. 129-141, 2018, ISSN: 1573-7217 (Electronic) 0167-6806 (Linking).

Links | BibTeX | Tags: Adult, Aged, Biomarkers, Breast, Breast cancer, Breast Density, Breast Neoplasms, classification, diagnosis, diagnostic imaging, ErbB-2, Estrogen, Female, genetics, Humans, mammographic density, Mammography, Middle Aged, pathology, Pregnancy, Progesterone, Receptor, Receptors, Risk Factors, Tumor

Clinically applicable optical imaging technology for body size and shape analysis: comparison of systems differing in design

Bourgeois, B; Ng, B K; Latimer, D; Stannard, C R; Romeo, L; Li, X; Shepherd, J A; Heymsfield, S B

Clinically applicable optical imaging technology for body size and shape analysis: comparison of systems differing in design Journal Article

In: Eur J Clin Nutr, 71 (11), pp. 1329-1335, 2017, ISSN: 1476-5640 (Electronic) 0954-3007 (Linking).

Links | BibTeX | Tags: Absorptiometry, Adolescent, Adult, Aged, Anthropometry, Body Composition, Equipment Design, Female, Humans, instrumentation, Male, Middle Aged, Optical Devices, Photon, Plethysmography, Reproducibility of Results, Shape Up, Young Adult

Engmann, N J; Scott, C G; Jensen, M R; Ma, L; Brandt, K R; Mahmoudzadeh, A P; Malkov, S; Whaley, D H; Hruska, C B; Wu, F F; Winham, S J; Miglioretti, D L; Norman, A D; Heine, J J; Shepherd, J; Pankratz, V S; Vachon, C M; Kerlikowske, K

Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors Journal Article

In: Cancer Epidemiology, Biomarkers & Prevention, 26 (6), pp. 930-937, 2017, ISSN: 1538-7755 (Electronic) 1055-9965 (Linking).

Links | BibTeX | Tags: Adult, adverse effects, Aromatase Inhibitors, Breast Density, drug effects, Female, Humans, Middle Aged, Tamoxifen

Hinton, B J; Fan, B; Ng, B K; Shepherd, J A

Dual energy X-ray absorptiometry body composition reference values of limbs and trunk from NHANES 1999-2004 with additional visualization methods Journal Article

In: PLoS One, 12 (3), pp. e0174180, 2017, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

Links | BibTeX | Tags: 80 and over, Absorptiometry, Adolescent, Adult, Age Factors, Aged, Body Composition, Child, diagnostic imaging, Extremities, Female, Humans, Male, methods, Middle Aged, Obesity, Photon, Reference Values, Sarcopenia, Sex Factors, Sexual Maturation, Shape Up, Torso, Young Adult

Kerlikowske, K; Ma, L; Scott, C G; Mahmoudzadeh, A P; Jensen, M R; Sprague, B L; Henderson, L M; Pankratz, V S; Cummings, S R; Miglioretti, D L; Vachon, C M; Shepherd, J A

Combining quantitative and qualitative breast density measures to assess breast cancer risk Journal Article

In: Breast Cancer Res, 19 (1), pp. 97, 2017, ISSN: 1465-542X (Electronic) 1465-5411 (Linking).

Links | BibTeX | Tags: Aged, Breast, Breast cancer risk, Breast Density, Breast Neoplasms, Case-Control Studies, Dense volume, diagnosis, diagnostic imaging, Early Detection of Cancer, epidemiology, Female, Humans, methods, Middle Aged, Neoplasm Staging, Odds Ratio, pathology, Public Health Surveillance, Risk Assessment, Risk Factors

Looker, A C; Isfahani, N Sarafrazi; Fan, B; Shepherd, J A

FRAX-based Estimates of 10-year Probability of Hip and Major Osteoporotic Fracture Among Adults Aged 40 and Over: United States, 2013 and 2014 Journal Article

In: Natl Health Stat Report, (103), pp. 1-16, 2017, ISSN: 2164-8344 (Print) 2164-8344 (Linking).

Links | BibTeX | Tags: 80 and over, Aged, Algorithms, epidemiology, Female, fracture risk prediction, Hip Fractures, Humans, Male, Middle Aged, National Health and Nutrition Examination Survey, Nutrition Surveys, Osteoporosis, Osteoporotic Fractures, Probability, United States

Maskarinec, G; Lim, U; Jacobs, S; Monroe, K R; Ernst, T; Buchthal, S D; Shepherd, J A; Wilkens, L R; Marchand, L Le; Boushey, C J

Diet Quality in Midadulthood Predicts Visceral Adiposity and Liver Fatness in Older Ages: The Multiethnic Cohort Study Journal Article

In: Obesity (Silver Spring), 25 (8), pp. 1442-1450, 2017, ISSN: 1930-739X (Electronic) 1930-7381 (Linking).

Links | BibTeX | Tags: Absorptiometry, Adiposity, Aged, Anthropometry, Body Image, Cohort Studies, Diet, Ethnic Groups, Exercise, Female, Food Quality, Humans, Intra-Abdominal Fat, Life Style, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Nutrition Assessment, pathology, Photon, physiopathology, Prospective Studies, Reproducibility of Results, Surveys and Questionnaires

Strand, F; Humphreys, K; Eriksson, M; Li, J; Andersson, T M; Tornberg, S; Azavedo, E; Shepherd, J; Hall, P; Czene, K

Longitudinal fluctuation in mammographic percent density differentiates between interval and screen-detected breast cancer Journal Article

In: Int J Cancer, 140 (1), pp. 34-40, 2017, ISSN: 1097-0215 (Electronic) 0020-7136 (Linking).

Links | BibTeX | Tags: Aged, Body Mass Index, Breast cancer, Breast Density, Breast Neoplasms, Cancer screening, diagnostic imaging, drug therapy, Early detection, Early Detection of Cancer, Female, Hormone Replacement Therapy, Humans, Interval cancer, Logistic Models, Longitudinal study, mammographic density, Mammography, methods, Middle Aged, Odds Ratio, pathology, Postmenopause

Yaghjyan, L; Tamimi, R M; Bertrand, K A; Scott, C G; Jensen, M R; Pankratz, V S; Brandt, K; Visscher, D; Norman, A; Couch, F; Shepherd, J; Fan, B; Chen, Y Y; Ma, L; Beck, A H; Cummings, S R; Kerlikowske, K; Vachon, C M

Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes Journal Article

In: Breast Cancer Res Treat, 165 (2), pp. 421-431, 2017, ISSN: 1573-7217 (Electronic) 0167-6806 (Linking).

Links | BibTeX | Tags: Adult, adverse effects, Breast, Breast cancer subtypes, Breast Density, Breast Neoplasms, Case-Control Studies, Disease Progression, epidemiology, Estrogen Replacement Therapy, etiology, Female, Humans, Menopause, Middle Aged, Odds Ratio, pathology, Population Surveillance, Postmenopausal hormone therapy, Risk, Tumor aggressiveness

Brandt, K R; Scott, C G; Ma, L; Mahmoudzadeh, A P; Jensen, M R; Whaley, D H; Wu, F F; Malkov, S; Hruska, C B; Norman, A D; Heine, J; Shepherd, J; Pankratz, V S; Kerlikowske, K; Vachon, C M

Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening Journal Article

In: Radiology, 279 (3), pp. 710-9, 2016, ISSN: 1527-1315 (Electronic) 0033-8419 (Linking).

Links | BibTeX | Tags: 3cb, 80 and over, Adult, Aged, Automation, Breast Density, Breast Neoplasms, diagnosis, Early Detection of Cancer, Female, Forecasting, Humans, methods, Middle Aged, Risk, three-compartment breast, Young Adult

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